Endocrine Abstracts

Diabetic ketoacidosis (DKA) is one of the most serious complications of diabetes mellitus (DM). We describe 2 cases of type-2 diabetic patients admitted by a surgical reason/trauma in which DM control was neglected. We present a 74-year-old patient with poor metabolic control (HbA1c 7,6%) treated with metphormin, sitagliptin and glibenclamide, admitted for orthopaedic surgery. During hospitalization, there were noted several episodes of disorientation with hyperglycae...

Introduction: Prolactin-producing pituitary adenomas are the most common pituitary tumors in clinical practice. In men they are more aggressive and their response to pharmacological treatment is unknown.Objective: Describe the clinical characteristics and response according to the treatment of a group of male patients with invasive macroprolactinomas.Materials and methods: A retrospective descriptive study, a series of cases, in 30...

Nicotinamide nucleotide transhydrogenase (NNT) is an integral protein of the inner mitochondrial membrane and plays a major role in maintaining the redox balance by catalysing the trans-hydrogenation between NADH and NADP+ and proton translocation across the mitochondrial membrane.Genetic variants in NNT have recently been reported in patients with familial glucocorticoid deficiency (FGD), combined mineralocorticoid and glucocorticoid deficiency...

Introduction: Evidence suggests that ionised calcium (iCa) and not total calcium is the physiologically relevant blood calcium component. Most blood gas (BG) analysers calculate iCa, but this is often ignored. We report our findings from a retrospective audit in medical in-patients and the potential benefit of this underused resource.Methods: A retrospective audit of admissions to two general medical/endocrine wards during January and February 2016. Data...

Objectives: To evaluate the prevalence of hypertension in patients with type 2 diabetes mellitus (T2DM) and to analyze the clinical characteristics, the degree of achieved control and the associated antihypertensive treatment.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, associated antihypertensive treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) was co...

Objectives: To evaluate the prevalence of cardiovascular disease (CVD) and associated risk factors in patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about several cardiovascular risk factors was collected (age, sex, smoking, hypertension and dyslipidemia). Also, data about coronary heart disease (CHD) and...

Objectives: To evaluate the characteristics of patients with type 2 diabetes mellitus (T2DM) attended in a rural primary care setting and to analyze associated antidiabetic treatment and metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a rural primary care setting. Data about age, sex, body mass index (BMI), associated antidiabetic treatment, and HbA1c was collected.Results: Seventy nin...

Objectives: To evaluate the use of antidepressant drugs in patients with type 2 diabetes mellitus (T2DM) and to analyse if these drugs are associated with a more deteriorated metabolic control.Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, T2DM evolution, body mass index (BMI), HbA1c and associated antidepressant treatment was collected. Statistical analysis was performed with SPS...

Pituicytomas are rare tumours, originating from modified glial cells called pituicytes. The lineage of these tumours remains a topic of debate. Approximately 65 cases have been reported in the literature to date, since being formally recognised in 2007. We report a case where the final diagnosis was made after second surgery for late recurrence.Case: A 54-year-old man presented with left sided visual disturbances in 1998 and underwent transcranial resect...

Background: Hypogonadism and erectile dysfunction have diverse causes. Hypogonadotrophic hypogonadism results from pituitary dysfunction, often caused by pituitary adenoma, pituitary surgery, radiotherapy, or use of prescription/non-prescription drugs. Rarer causes should be considered during initial investigation of patients with erectile dysfunction. We present a case of secondary hypogonadism and how further investigations eventually led to the underlying diagnosis.<p c...